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AMS Biotechnology announces a HER2 control cell-line array that is proven as an effective slide quality control for human epidermal growth factor receptor 2 (HER2) expression in breast-cancer tissue samples. This FFPE cell-pellet microarray delivers a full dynamic range of HER2, estrogen receptor (ER), and progesterone receptor (PR) expression, validated by the Ventana system, to give immunohistochemical (IHC) data in strong concordance with the routinely processed tissue sample sections. Using cell-line controls significantly lowers the costs of IHC examinations, fluorescence in situ hybridization, and NGS applications while enabling high levels of standardization and reliability. The new HER2 cell-line microarray is perfect for cancer research establishments and laboratories that require results while not compromising on consistency or quality.

Leukapheresis Products

Lonza has expanded its renowned human primary cell offerings with the launch of fully customizable, high-quality cryopreserved Leukopaks. The frozen Leukopaks enable long-distance shipping of leukapheresis products without the concern of reduced cell viability encountered with fresh Leukopaks. Being suitable for long-term storage in research labs, the cryopreserved Leukopaks will also allow immediate access to viable cells for greater convenience and workflow flexibility. They come in a range of sizes, including packs of 2.5, 5, and 9.5 billion cells, which can be subdivided into separate smaller bags for greater convenience. Specific donor characteristics like age, gender, and human leukocyte antigen (HLA) type are also available, with a wide range of recallable donors and several product-testing options, using a unique costing structure that allows customers to pay only for the customization they need. A Leukopak is an enriched, leukapheresis-derived product containing high concentrations of peripheral blood mononuclear cells, such as T cells, B cells, and monocytes. Such cells are critical for immunotherapy research and for optimizing cell-therapy process development before progressing to full clinical manufacture.

Single-Cell Analysis Reagent

Immudex ApS announces the launch of dCODE Dextramer (RiO) reagents. These DNA-barcoded MHC Dextramer reagents are designed to be compatible with the BD Rhapsody system and used for multiplexing, allowing the identification of many different T-cell specificities in the same sample. dCODE Dextramer reagents are used to determine T-cell antigen-specificity at single-cell resolution, providing simultaneous information on gene expression and surface-marker expression. By creating personalized dCODE Dextramer libraries, it is possible to profile T cells and get a new understanding of T-cell immunity. dCODE Dextramer reagents consist of a dextran polymer backbone carrying multiple major histocompatibility complex (MHC)-peptide complexes, a corresponding unique DNA barcode oligo, and R-phycoerythrin for sorting of dCODE Dextramer positive cells before loading the sample into the BD Rhapsody system. The unique DNA barcode oligo comprises BD Rhapsody-compatible PCR handle sequences for PCR amplification, a unique molecular identifier (UMI) sequence, and a DNA barcode sequence that specifies the MHC-peptide specificity.

Nucleic-Acid Quantification

Tecan has launched the Frida Reader for the Fluent Automation Workstation, offering researchers the ability to quantify nucleic acids without sample loss. This unique solution performs UV absorbance-based quantification and purity assessment in a hanging drop, avoiding the consumption of rare and precious samples following nucleic acid purification (NAP). Efficient NAP is crucial prior to applications such as NGS or PCR/quantitative PCR, but laboratories working with low-volume, high-value samples cannot always afford to lose a portion of their samples for quantification and purity assessment. The Frida Reader eliminates this issue by allowing assessment of sample quality and quantity without any sample loss, aspirating the sample back into the pipette tip after performing hanging-drop absorbance measurements. It uses four separate wavelengths—230 nm, 260 nm, 280 nm, and 320 nm—to allow real-time nucleic acid quantification in the 5 ng/μL–1,000 ng/μL range, as well as quality control measurements to identify protein contamination.

T-Cell Transduction

Whether you’re working with difficult-to-transduce cells like primary T cells or just want to ensure high transduction efficiency, System Bioscience’s TransDux reagents are ready to deliver. Our newer TransDux MAX Lentiviral Transduction Reagent can increase transduction efficiencies by up to eightfold compared to polybrene, while our original TransDux formulation is still available for researchers who are not yet ready to make the change. TransDux MAX comes in an easy-to-use, two-component format (TransDux and MAX Enhancer) that is good for 100 transduction reactions. Simply mix both reagents into conditioned media from target cells, and infect with your lentivirus of choice for a higher level of transduction efficiency. TransDux MAX is broadly compatible and does not interfere with downstream gene expression or functional assays.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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